16 High Protein Casseroles with 20+ G Protein

Not every casserole pulls its weight on protein — a lot of them lean on pasta, rice, or potatoes to bulk up the serving size instead.

Most of these high protein casserole recipes are great for meal prep, family dinners, and leftovers the next day. They’re hearty, easy to portion, and many can be made ahead when you know the week is going to be busy.

If you’re looking for high protein dinners that are practical and satisfying, these casseroles are a good place to start

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1. Ground Chicken Casserole with Zucchini And Eggplant

Ground chicken layered with roasted eggplant and zucchini, then baked under mozzarella and parmesan. The two cheeses do a lot of the protein work here on top of the chicken, and it stays lean since there’s no pasta or rice mixed in. Est. 310 kcal · 25g protein per serving (8 servings).

→ Get the full recipe: Ground Chicken Casserole with Zucchini And Eggplant

2. Chicken, Zucchini, and Cheese Casserole

Shredded chicken and sliced zucchini in a simple cheddar sauce.

It’s one of the lighter casseroles here calorie-wise, but the cheese and chicken combination still keeps protein solidly over 20 grams a serving. Est. 300 kcal · 24g protein per serving (6 servings).

→ Get the full recipe: Chicken, Zucchini, and Cheese Casserole

3. Chicken Spinach Cauliflower Casserole

Chicken and cauliflower in a cheddar cream sauce with spinach stirred through.

Only 4 servings in the recipe means the protein per plate runs the highest of any casserole on this list. Est. 380 kcal · 34g protein per serving (4 servings).

→ Get the full recipe: Chicken Spinach Cauliflower Casserole

4. Viral Baked Spaghetti Pizza Styled Casserole

Spaghetti and Italian sausage baked under a biscuit-dough crust with mozzarella and pepperoni on top.

It’s the most indulgent recipe on this list — worth knowing going in — but the sausage and cheese still keep it over the 20-gram mark.

Est. 450 kcal · 21g protein per serving (8 servings).

→ Get the full recipe: Viral Baked Spaghetti Pizza Styled Casserole

5. Baked Ground Beef Pasta Casserole

Ground beef and penne baked in a simple crushed-tomato sauce with three cheeses stirred and layered in.

It’s a straightforward weeknight bake that clears 20 grams of protein without needing any tricks.

Est. 380 kcal · 21g protein per serving (8 servings).

→ Get the full recipe: Baked Ground Beef Pasta Casserole

6. Chicken and Broccoli Rice Casserole

Shredded chicken, rice, and broccoli baked in a cheddar sauce. It’s a full meal in one dish, and the chicken-to-rice ratio is high enough that protein doesn’t get diluted by the starch.

Est. 370 kcal · 26g protein per serving (6 servings).

→ Get the full recipe: Chicken and Broccoli Rice Casserole

7. Chicken Casserole With Spinach, Eggs and Cheese – Strata

A savory bread pudding built from chicken, eggs, spinach, and cheddar.

Two protein sources — chicken and eggs — stacked in one dish is what pushes this past 20 grams even with bread mixed in.

Est. 340 kcal · 25g protein per serving (8 servings).

→ Get the full recipe: Chicken Casserole With Spinach, Eggs and Cheese – Strata

8. Potato Casserole with Ground Chicken and Spinach

Thin-sliced potatoes layered with ground chicken and spinach in a creamy sauce.

It leans more potato-forward than the other bakes here, so it lands right around the 20-gram line rather than well past it.

Est. 350 kcal · 21g protein per serving (6 servings).

→ Get the full recipe: Potato Casserole with Ground Chicken and Spinach

9. Potatoes And Ground Beef Broccoli Casserole

Ground beef, broccoli, and sliced potatoes under a cheddar sauce. Similar build to the chicken-and-potato version above, just with beef instead — a good one to rotate between the two.

Est. 370 kcal · 21g protein per serving (6 servings).

→ Get the full recipe: Potatoes And Ground Beef Broccoli Casserole

10. Cheesy Tuna Noodle Casserole with Peas

A classic tuna noodle bake with peas and a crunchy breadcrumb topping.

Canned tuna and cheddar together just clear 20 grams per serving — this is the one on the list closest to that line, so don’t skimp on the tuna.

Est. 400 kcal · 20g protein per serving (6 servings).

→ Get the full recipe: Cheesy Tuna Noodle Casserole with Peas

11. Macaroni Tuna Casserole Bake

Tuna and elbow macaroni baked with cheddar and a mayonnaise-based sauce, plus a panko topping for crunch.

Fewer servings than most tuna bakes on this list, so the protein count runs a bit higher per plate.

Est. 420 kcal · 23g protein per serving (4 servings).

→ Get the full recipe: Macaroni Tuna Casserole Bake

12. Baked Ziti Pasta with Bolognese Sauce and Cheese

A slow-simmered beef bolognese baked into ziti with ricotta, mozzarella, and parmesan.

Three cheeses plus the beef make this one of the higher-protein bakes here even split across 8 servings.

Est. 420 kcal · 27g protein per serving (8 servings).

→ Get the full recipe: Baked Ziti Pasta with Bolognese Sauce and Cheese

13. Old Fashioned Baked Spaghetti and Beef Pie

Spaghetti bound with eggs and parmesan into a “pie” crust, then filled with a beef-and-marinara layer and topped with ricotta and mozzarella.

It’s the richest recipe on this list by far, and the protein count reflects that — worth saving for a night you’re not watching calories closely.

Est. 550 kcal · 40g protein per serving (4 servings).

→ Get the full recipe: Old Fashioned Baked Spaghetti and Beef Pie

14. Lazy Baked Cheese Ravioli Lasagna

Frozen cheese ravioli layered with marinara and extra ricotta and mozzarella instead of building a lasagna from scratch.

The cheese-filled ravioli themselves add protein on top of what’s layered around them.

Est. 430 kcal · 26g protein per serving (8 servings).

→ Get the full recipe: Lazy Baked Cheese Ravioli Lasagna

15. One Skillet Cheeseburger Mac and Cheese

Ground beef and elbow macaroni cooked together in one pan with a cheddar-American cheese sauce and classic burger seasonings.

Only 4 servings and a full pound of beef means this one runs high in protein and in calories.

Est. 500 kcal · 34g protein per serving (4 servings).

→ Get the full recipe: One Skillet Cheeseburger Mac and Cheese

16. One Pan Salmon with Lemon Orzo Skillet

Salmon fillets seared and finished over lemony orzo with spinach and parmesan, all in one pan.

It’s technically a skillet rather than a baked casserole, but it earns its spot here — salmon is one of the highest-protein options on the whole list.

Est. 420 kcal · 30g protein per serving (4 servings).

→ Get the full recipe: One Pan Salmon with Lemon Orzo Skillet